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Tadalafil 20 mg administered to healthy male subjects produced no significant difference when compared with placebo in supine systolic and diastolic blood pressure (difference inside the mean maximal decrease of 1.6/0.8 mm Hg, respectively) along with standing systolic and diastolic blood pressure levels (difference within the mean maximal decrease of 0.2/4.6 mm Hg, respectively). In addition, there is no significant effect on heartrate.